Interaction with other drugs
With the simultaneous use of Arcoxia and anticoagulants, you need to carefully monitor the international normalized ratio (INR) - the ratio of the prothrombin time of this patient to the average prothrombin time - especially in the first few days of therapy.
The simultaneous use of this medication with large doses of acetylsalicylic acid increases the risk of ulcerative lesions of the mucous membrane of the digestive tract. Simultaneous therapy with tacrolimus and cyclosporins increases the likelihood of nephrotoxicity.
The medicine may interact with certain oral contraceptives, increasing the risk of developing thromboembolism, so be sure to tell your doctor about the hormones you are taking before starting therapy - they may need to be replaced.
Etoricoxib binds to human plasma proteins by 92% with a concentration range from 0.05 to 5 μg / ml. Buy etoricoxib In humans, the volume of distribution in equilibrium (Vdss) is about 120 l.
Etoricoxib crosses the placental barrier in rats and rabbits, as well as through the blood-brain barrier in rats.
The drug "Arkoxia" (tablets): instructions for use and dosage
In no case should you use this medication yourself. http://www.medicines.org.uk/emc/product/743/smpc Only a doctor can prescribe and talk about how to take Arkoxia (tablets) correctly. The instruction contains only general recommendations..
Dosage, as a rule, depends on the patient's condition and the type of his problem. For example, with osteoarthritis, it is most often recommended to take one tablet with a dosage of 60 mg per day, regardless of food intake.
The maximum daily dose for patients with spondylitis and rheumatoid arthritis is 90 mg of the active substance. With gouty arthritis, you can take 120 mg per day. The duration of therapy is determined by the attending physician.
Nevertheless, the maximum allowable treatment period is 8-10 days, after which the reception must be stopped at least temporarily.
With caution, the medicine is prescribed for people suffering from liver failure - the daily dose in such cases should not exceed 60 mg.